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题    目: Structure, dynamics and function of biomolecules and molecular complexes

报告人: Professor Feng Ding

Physics of Astronomy, Clemson University

时    间: 7月5日（周三）10:00-11:00

地    点: 吕志和楼三层大厅

主持人: 齐志研究员，徐莉梅教授

摘 要:

Our lab focuses on uncovering the structure, dynamics, and function interrelationship of biomolecules and molecular complexes via multiscale modeling. which is crucial for our understanding of biological systems by bridging gaps of time and length scales between experimental observations and underlying molecular systems. One of the major challenges is to reach the biologically relevant time and length scales in silico. Over the years, we have been pioneering the development of discrete molecular dynamics(DMD) simulation methodology for rapid and accurate characterization of the structure and dynamics of biomolecules, including proteins, nucleotides, small molecules, lipids, and nanoparticles. We have successfully applied the DMD methodology to study protein/RNA folding, protein design, protein-ligand docking, protein misfolding and amyloid aggregation, and recently the nano-bio interface. Here, I will focus my discussion on the application of DMD simulation in understanding the molecular mechanisms of amyloid aggregation, the relationship with Liquid-Liquid Phase Separation, and exploring novel approaches to mitigate aggregation-mediated cytotoxicity.

报告人简介：

Dr. Feng Ding received his BS degree in Physics from the Department of Intensive Instruction at Nanjing University (NJU) in 1997. After two years as a graduate student in the Physics Department of NJU, he joined the Center for Polymer Studies at Boston University and obtained his PhD in Physics in January 2004, under the supervision of Prof. Eugene Stanley. From 2004 to 2012, Dr. Ding worked with Prof. Nikolay Dokholyan at the University of North Carolina at Chapel Hill as a postdoctoral fellow (2004-2006), research associate (2006-2008), and later research assistant professor (2008-2012). Dr. Ding joined Clemson in August 2012. Professor Ding Feng serves as an editor for multiple academic journals such as PROTEINS, Biomedicines, and Scientific Reports. He is mainly engaged in the research of Computational Biology and Structural Bioinformatics, and has made a number of important work in the research of Protein folding, protein aggregation, and nano-biological intersection. The Discrete Molecular Dynamics (DMD) method developed by him has been widely used, and the molecular simulation research on the direction of nano-biological intersection has won the NSF CAREER award in 2016.